OBJECTIVES
The overall objective of
the project is to design new molecules that can interfere with several
processes involved in Alzheimer's disease. Particular attention will be
paid to targeting acetylcholinesterase, oxidation and amyloid plaque
formation.
Specific objectives
O.1. Synthesis and physico-chemical
characterization of new nitrogen-containing heterocyclic analogues
O.2. Molecular modeling of the
interaction with acetylcholinesterase
O.3. Biological evaluation
O.4. Project management, dissemination and
communication